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An emerging cellular immunotherapy for cancer is based on the cytolytic activity of natural killer (NK) cells against a wide range of tumors. Although in vitro activation wholesale steroids, or “priming wholesale steroids,” of NK cells by exposure to pro inflammatory cytokines, such as interleukin (IL) 2, has been extensively studied, the biological consequences of NK cell activation in response to target cell interactions have not been thoroughly characterized. We investigated the consequences of co incubation with K562, CTV 1 wholesale steroids, Daudi RPMI 8226, and MCF 7 tumor cell lines on the phenotype, cytokine expression profile, and transcriptome of human NK cells.

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